產品介紹

µ-conotoxin GIIIB（µ-芋螺毒素 GIIIB）

Selective blocker of Na_v1.4 channels(鈉離子通道Na_v1.4選擇性阻斷劑)

µ-conotoxin GIIIB is a 22-mer peptide originally isolated from the venom of the piscivorous marine snail Conus geographus. µ-conotoxin GIIIB adopts a compact structure consisting of a distorted 3₁₀-helix and a small ß-hairpin. µ-conotoxin GIIIB is stabilized by three disulphide bridges and is highly enriched in lysine and arginine residues, forming potential sites of interaction with Na channels. An unusual feature is the presence of three hydroxyproline residues. µ-conotoxin GIIIB is a useful probe to discriminate between neuronal and muscle sodium channels as it exhibits at least a 1000-fold specificity for muscle versus nerve sodium channels. µ-Conotoxin GIIIB selectively blocks Na_v1.4(µ1) voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM.µ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na⁺ channel. 

µ-conotoxin GIIIB 技術資料

氨基酸序列：

Arg-Asp-Cys³-Cys⁴-Thr-Hyp-Hyp-Arg-Lys-Cys¹⁰-Lys-Asp-Arg-Arg-Cys¹⁵-Lys-Hyp-Met-Lys-Cys²⁰-Cys²¹-Ala-NH₂ 

二硫鍵： Cys³-Cys¹⁵, Cys⁴-Cys²⁰ and Cys¹⁰-Cys²¹ 

長度 (aa)： 22 

分子式： C₁₀₁H₁₇₅N₃₉O₃₀S₇ 

分子量：2640.26 Da 

外觀：White lyophilized solid 

可溶性：water and saline buffer 

CAS 號：not available 

來源： Synthetic  

純度：> 97 %

產品信息